Directory

Andrea Hoffmann

Group Lead, Research Scientist

University of Dayton Research Institute: Fuels and Combustion

Profile

Dr. Hoffmann serves as the Group Lead of the Environmental Microbiology Group within the UDRI Fuels & Combustion Division. Dr. Hoffmann is a Research Scientist with expertise in Molecular Biology, Microbiology, Toxicology, Analytical Chemistry, and metabolomics/proteomics-based Mass Spectrometry. Dr. Hoffmann oversees the Aviation Fuel Microbial Research Program including the testing and mitigation of biocontamination, the development of synthetic biology applications to generate novel high energy fuel compounds, and bio-derived enzymatic and molecular tools.

Research

• Identification of Microbial Contamination in Aviation Fuel Systems
• Development and screening of novel biocides
• Synthetic biology application for the generation of novel high energy fuel compounds
• Bio-derived and genetically engineered enzymatic and molecular tools
• Synthetic microbiology, and analytical chemistry with expertise in discovery proteomics and metabolomics
• User-based computational analysis for proteomics and metabolomics
• In vitro biochemical assays, cell-based assays and in vivo models to investigate multiple cellular processes and phenotypes

Education

• Ph.D., Biomedical Sciences, Wright State University, Dayton, OH, 2004
• M.S., Biology, Saarland University, Saarbrücken, Germany, 1998

Honors

• Young Investigator Award, International Conference on Proteomics and Bionformatics, Chicago, IL, 2014

Selected Publications

• D. Kim, P. Anantharam, A. Hoffmann, M.L. Meade, N Grobe, J.M. Gearhart, E.M. Whitley, B. Mahama, W.K. Rumbeiha, “Broad Spectrum Proteomics Analysis of the Inferior Colliculus following Acute Hydrogen Sulfide Exposure”, Toxicol Appl Pharmacol. Vol. 355, pp. 28-42, 2018.
• M.L. Meade, A. Hoffmann, M.K. Makley, T.H. Snider, J.J. Schlager, J.M. Gearhart, “Quantitative proteomic analysis of the brainstem following lethal sarin exposure”, Brain Res. Vol. 1611, pp. 101-13, 2015.
• D.A. Mahle, M.C. Moulton, N. Grobe, S. Pak, A.M. Lowman, M. Chapleau, M.W. Grogg, S.T.Law, M.K. Makley, L. Naraynan, A. Hoffmann, “Mechanistic Interpretation of Hypobaria and Hyperoxia using Metabolomics and Proteomics,” AFRL-RH-WP-TR-2018-0001
• K.O. Yu, M.L. Meade, R. Capati, J.J. Schlager, D.R. Mattie, R.A. James, M.J. Ray, D.A. Dixon, L.K. Stolle, T.R. Sterner, A. Hoffmann, “Toluene Dose-Response and Proteomic Study of Neuronal Cell Lines,” AFRL-RH-FS-TR-2015-0086