Pothitos M. Pitychoutis

Contact Information

Curriculum Vita

Pothitos M. Pitychoutis

Assistant Professor

  • Full-Time Faculty


Dr. Pothitos Pitychoutis earned a B.Sc. in Biology from the National & Kapodistrian University of Athens, Greece in 2005, and an M.Sc. in Molecular Medicine/Neurobiology and a Ph.D. in 2010 from the Medical School of the same University. The next year he served as junior lecturer in the Department of Pharmacology of the Medical School of Athens and afterwards he pursued postdoctoral training at INSERM UMR-839, Institut du Fer à Moulin in Paris, France, on the basis of a Neuropôle de Recherche Francilien (NeRF) fellowship and at the Biomedical Research Foundation of the Academy of Athens, Greece (BRFAA). In 2013 Dr. Pitychoutis joined the Department of Biology as an Assistant Professor in Neuroscience.

Professional Affiliations

  • Society for Neuroscience (SfN)
  • Hellenic Society for Neurosciences (HSFN)
  • Greek Society of Pharmacology (GSP)
  • Hellenic Society of Bioscientists (PEV)
  • International Brain Research Organization (IBRO)
  • European College of Neuropsychopharmacology (ECNP)
  • Federation of European Neuroscience Societies (FENS)
  • Society for Behavioral Neuroendocrinology (SBN)

Research Interests

Neuropsychopharmacology and Behavioral Neuroscience:

The goal of our research is to better understand the behavioral, neurochemical and molecular mechanisms underlying neuropsychiatric disorders and their treatment. A major research line of our lab, concerns the sex-dependent neurobiological adaptations that underlie the actions of antidepressant drugs and stress at the preclinical level with the ultimate goal to identify novel targets for individualized and sex-oriented psychopharmacotherapies. In this context, experiments are guided by neuropharmacological or physiological hypotheses and a combination of rodent stress models, neurochemical and molecular methods are implemented.

Major research areas of our lab include:

  • Sex differences in animal models of depression and antidepressant response
  • Role of serotonin in the neurobiology of neuropsychiatric disorders such as major depression and schizophrenia
  • Individual differences in response to stress and antidepressants
  • Neuroimmunopharmacology of major depression

Selected Publications

Franceschelli A., Herchick S., Thelen C., Papadopoulou-Daifoti Z., Pitychoutis P.M.* (2014) "Sex differences in the chronic mild stress model of depression." Behavioural Pharmacology, 25: 372-383

Pitychoutis  P.M., Sanoudou D., Papandreou M., Nasias D, Kouskou M, Tomlinson C.R., Tsonis P.A., Papadopoulou-Daifoti Z (2014) "Forced swim test induces divergent global transcriptomic alterations in the hippocampus of high versus low novelty-seeker rats." Human Genomics, 25;8(1):4. Highly Accessed

Pitychoutis PM, Kokras N, Sanoudou D, Dalla C, Papadopoulou-Daifoti Z (2013) "Pharmacogenetic considerations for late-life depression therapy." Expert Opin Drug Metab Toxicology, 9(8):989-99.

Xilouri M, Brekk OR, Landeck N, Pitychoutis PM, Papasilekas T, Papadopoulou-Daifoti Z, Kirik D, Stefanis L (2013). "Boosting Chaperone-Mediated Autophagy mitigates alpha-synuclein-mediated neurodegeneration in an animal model of Parkinson’s disease." Brain, 136: 2130-2146

Athanasopoulos C, Pitychoutis PM, Messari I, Lionis C, Papadopoulou-Daifoti Z (2013). "Is drug utilization in Greece sex-dependent? A population based study". Basic Clin Pharmacol Toxicol, 112(1):55-62. 

Pitychoutis PM, Dalla C, Sideris AC, Tsonis PA, Papadopoulou-Daifoti Z (2012). "5-HT1A, 5-HT2A, and 5-HT2C receptor mRNA modulation by antidepressant treatment in the chronic mild stress model of depression: sex differences exposed". Neuroscience 210: 152-167. 

Xilouri M, Kyratzi E, Pitychoutis PM, Papadopoulou-Daifoti Z, Vila M, Maniati M, Ulusoy A, Kirik D, Park D, Wada K, Stefanis L (2012). "Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system". Hum Mol Genet, 21(4):874-889.

Pitychoutis PM, Pallis E, Mikail HG, Papadopoulou-Daifoti Z (2011). "Individual differences in novelty-seeking predict differential responses to chronic antidepressant treatment through sex- and phenotype-dependent neurochemical signatures." Behav Brain Res, 223(1):154-168.

Dalla C, Pitychoutis PM, Kokras N, Papadopoulou-Daifoti Z (2010). "Sex differences in the neurobiological substrate of depression and antidepressant response". Basic Clin Pharmacol Toxicol, 106: 226-233. 

Pitychoutis PM, Zisaki A, Dalla C, Papadopoulou-Daifoti Z (2010). "Pharmacogenetic insights into depression and antidepressant response: does sex matter?" Curr Pharm Des, 16: 2214-2223.

Pitychoutis PM & Papadopoulou-Daifoti Z (2010). "Of depression and immunity: does sex matter?" Int J Neuropsychopharmacol, 13: 675-689.

Pitychoutis PM, Griva E, Ioannou K, Tsitsilonis OE, Papadopoulou-Daifoti Z (2009). "Chronic antidepressant treatment exerts sexually dimorphic immunomodulatory effects in an experimental model of major depression: do females lack an advantage?" Int J Neuropsychopharmacol, 12: 1157-1163.

Pitychoutis PM, Nakamura K, Tsonis PA, Papadopoulou-Daifoti Z (2009). "Neurochemical and behavioral alterations in an inflammatory model of depression: sex differences exposed". Neuroscience, 159: 1216-1232.